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Flowchart of the study design. Genomic and transcriptomic data were extracted from the GEO database ( GSE83448 ).

Journal: Biomolecules and Biomedicine

Article Title: S-palmitoylation-related genes in Crohn’s disease: Bioinformatic identification and validation

doi: 10.17305/bb.2025.13221

Figure Lengend Snippet: Flowchart of the study design. Genomic and transcriptomic data were extracted from the GEO database ( GSE83448 ).

Article Snippet: The gene expression microarray dataset GSE83448 was obtained from the National Center for Biotechnology Information Gene Expression Omnibus (NCBI GEO; https://www.ncbi.nlm.nih.gov/geo/ ) [ ].

Techniques:

Differentially expressed S-palmitoylation-related genes in 39 CD intestinal biopsies and 14 healthy controls. (A) PCA for GSE83448 . (B) Volcano plot illustrating 3743 DEGs. (C) Venn diagram depicting the overlap between DEGs and S-palmitoylation-related genes. (D) Heatmap representing the 23 SP-DEGs in CD and healthy controls. (E) Boxplots comparing the 23 SP-DEGs in CD and healthy controls. Abbreviations: CD: Crohn’s disease; PCA: Principal component analysis; DEGs: Differentially expressed genes; SP-DEGs: S-palmitoylation-related differentially expressed genes.

Journal: Biomolecules and Biomedicine

Article Title: S-palmitoylation-related genes in Crohn’s disease: Bioinformatic identification and validation

doi: 10.17305/bb.2025.13221

Figure Lengend Snippet: Differentially expressed S-palmitoylation-related genes in 39 CD intestinal biopsies and 14 healthy controls. (A) PCA for GSE83448 . (B) Volcano plot illustrating 3743 DEGs. (C) Venn diagram depicting the overlap between DEGs and S-palmitoylation-related genes. (D) Heatmap representing the 23 SP-DEGs in CD and healthy controls. (E) Boxplots comparing the 23 SP-DEGs in CD and healthy controls. Abbreviations: CD: Crohn’s disease; PCA: Principal component analysis; DEGs: Differentially expressed genes; SP-DEGs: S-palmitoylation-related differentially expressed genes.

Article Snippet: The gene expression microarray dataset GSE83448 was obtained from the National Center for Biotechnology Information Gene Expression Omnibus (NCBI GEO; https://www.ncbi.nlm.nih.gov/geo/ ) [ ].

Techniques:

Functional enrichment analysis of SP-DEGs in the GSE83448 dataset. (A) The bubble plot illustrates key enriched terms across various categories. BP denotes biological processes; CC indicates cellular components; and MF represents molecular functions. (B) The circle map emphasizes BPs associated with S-palmitoylation. (C) The bar plot presents the results of the functional enrichment analysis, ranked by statistical significance. (D) The Circos plot visualizes the functional associations across categories. Abbreviations: SP-DEGs: S-palmitoylation-related differentially expressed genes; BP: Biological process; CC: Cellular component; MF: Molecular function.

Journal: Biomolecules and Biomedicine

Article Title: S-palmitoylation-related genes in Crohn’s disease: Bioinformatic identification and validation

doi: 10.17305/bb.2025.13221

Figure Lengend Snippet: Functional enrichment analysis of SP-DEGs in the GSE83448 dataset. (A) The bubble plot illustrates key enriched terms across various categories. BP denotes biological processes; CC indicates cellular components; and MF represents molecular functions. (B) The circle map emphasizes BPs associated with S-palmitoylation. (C) The bar plot presents the results of the functional enrichment analysis, ranked by statistical significance. (D) The Circos plot visualizes the functional associations across categories. Abbreviations: SP-DEGs: S-palmitoylation-related differentially expressed genes; BP: Biological process; CC: Cellular component; MF: Molecular function.

Article Snippet: The gene expression microarray dataset GSE83448 was obtained from the National Center for Biotechnology Information Gene Expression Omnibus (NCBI GEO; https://www.ncbi.nlm.nih.gov/geo/ ) [ ].

Techniques: Functional Assay